Ether 11:13 "The prophets mourned and withdrew"

We learn that the Spirit will withdraw himself from anyone who refuses to listen to his promptings or offends him. The prophets (and missionaries in our day) can likewise only do so much to try to bring a people to repentance. If the people are stubborn or have hardened their hearts, then the prophets will simply have to move on. Of course this would be very difficult because they would feel Godly love for the people and understand the grievous mistake that the people are making.